Study of Neuroprotective Effects of Green Tea Antioxidant on Spinal Cord Injury of Rat
نویسندگان
چکیده مقاله:
Purpose: Recent studies revealed the neuroprotective effects of green tea antioxidant on experimental cerebral ischemia, but these effects on spinal cord injury (SCI) has not yet been studied.Materials and Methods: Rats were randomly divided into three groups of 18 rats each as follows: sham group (laminectomy), control group (SCI) and experimental group (EGCG). Spinal cord samples were taken 24 h after injury and studied for determination of lipid peroxidation levels and TUNEL reaction. Behavioral testing was performed weekly upto six weeks post-injury. Then, the rats were euthanized for histopathological assessment.Results: The results showed that lipid peroxidation levels were significantly decreased in experimental group. EGCG significantly reduced TUNEL-positive rate. Also, EGCG reduced significantly lesion area, and improved behavioral function more than the control group.Conclusion: EGCG treatment decreased secondary spinal cord injury.
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عنوان ژورنال
دوره 7 شماره 28
صفحات 0- 0
تاریخ انتشار 2009-11
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